Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells

Table 4 Top 10 transcripts underexpressed in ileal mucosa ranked by increasing absolute log₂ fold change (logFC) in asthma vs controls. FDR—false-discovery ratio (Benjamini-Hochberg)

logFC	Average expression	p_FDR	Gene	Gene name and function
− 1.93	6.94	0.028	LOC440525	Probe ILMN_1662409—unknown function; increased expression in the intestine after congenital heart defect surgery
− 1.92	7.86	0.017	LOC731789	Probe ILMN_3233239—unknown function; related to rs11015207 that associates with maximal oxygen uptake response after training
− 1.85	7.91	0.009	PDE4A	Phosphodiesterase 4A—regulates cellular cyclic adenosine monophosphate (cAMP); related to asthma; asthma drug target
− 1.84	9.00	0.017	LOC100129201	Probe ILMN_3263918—unknown function; might be hypertension-related
− 1.84	7.31	0.036	PCK1	Phosphoenolpyruvate Carboxykinase 1—controls gluconeogenesis; regulates the citric acid cycle
− 1.78	7.67	0.016	TAF13	TATA-Box Binding Protein Associated Factor 13—involved in initiation of transcription by RNA polymerase II; its mutations associate with schizophrenia
− 1.76	6.70	0.027	LOC100130422	Probe ILMN_3242709—function unknown
− 1.74	8.55	0.033	HINT3	Histidine Triad Nucleotide Binding Protein 3—may act on alpha-phosphate of ribonucleotides
− 1.74	7.13	0.017	KREMEN2	Kringle Containing Transmembrane Protein 2—by enhancing endocytosis of LRP5 and LRP6 inhibits signalling through Wnt/β-catenin pathway
− 1.71	7.90	0.017	TAF13	TATA-Box Binding Protein Associated Factor 13

ISSN: 1710-1492