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Table 3 Top 20 genes differentially expressed in ileal mucosa ranked by absolute log2 fold change (logFC) in asthma vs controls. FDR—false-discovery ratio (Benjamini-Hochberg)

From: Expression profiling of ileal mucosa in asthma reveals upregulation of innate immunity and genes characteristic of Paneth and goblet cells

logFC pFDR Gene Gene name and function
3.01 0.015 FCGBP Fc Fragment Of IgG Binding Protein—binds IgG Fc and MUC2
2.78 0.015 MUC2 Mucin 2, Oligomeric Mucus/Gel-Forming—forms mucus layer protecting the intestinal (and airway) epithelium
2.73 0.024 DEFA1B Defensin Alpha 1B—antimicrobial peptide
2.61 0.012 OLFM4 Olfactomedin 4—intestinal stem cell marker, also secreted by neutrophils during the formation of extracellular traps (NETs)
2.61 0.013 C1QB Complement C1q B Chain—the complement bridges innate and adaptive immunity
2.48 0.021 ITLN1 Intelectin 1—binds bacterial glycans; adipokine (also known as omentin)
2.46 0.040 REG4 Regenerating Family Member 4—lectin-like protein binding manno-oligosaccharides
2.43 0.023 LYZ Lysozyme—cleaves bacterial peptidoglycan
2.39 0.018 PLA2G2A Phospholipase A2 Group IIA—phospholipase degrading bacterial membrane phospholipids; promotes Paneth cell development
2.36 0.017 DEFA6 Defensin Alpha 6—antimicrobial peptide
2.34 0.029 LOC100134294 Probe ILMN_3238960—unknown function; upregulated in ulcerative colitis
2.29 0.013 M160 CD163 Molecule Like—belongs to cysteine-rich scavenger receptors; may characterize a subset of CD163+colonic CD14+cells
2.28 0.021 GCG Glucagon—the transcript encodes glucagon and three other enterohormones, including GLP-2 that stimulates crypt proliferation and gut barrier function
2.22 0.020 CEACAM5 CEA Cell Adhesion Molecule 5—cell adhesion molecule; may be elevated in various cancers
2.20 0.017 SST Somatostatin—peptide hormone best known for inhibiting the pituitary; also interacts with enterohormones
2.20 0.007 PDGFRA Platelet Derived Growth Factor Receptor Alpha; its activity associates with eosinophilia; PDGFRA rearrangement may cause chronic eosinophilic leukemia
2.19 0.017 FCGBP Fc Fragment Of IgG Binding Protein (another probe)
2.17 0.020 CD24 CD24 Molecule—a peptide binding lectins; expressed by B-cells and granulocytes
2.17 0.038 HLA-DQA1 Major Histocompatibility Complex, Class II, DQ Alpha 1—presents antigens; its variants associate with autoimmunity against infliximab in inflammatory bowel diseases
2.13 0.043 ITLN2 Intelectin 2—may bind bacterial polysaccharides
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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