Table 1 Double-Blind Placebo-Controlled Studies of Local Nasal Immunotherapy
From: Local Nasal Specific Immunotherapy for Allergic Rhinitis
| Author, Year | Age Range (yrs) | No of Patients (Active/Placebo) | Allergen | Duration | Type of Extract |
|---|---|---|---|---|---|
| Johansson, 1979 [13] | Ad | 12/11 | Grass | 14 wk | Aqueous, modified |
| Nickelsen, 1981 [14] | 16-66 | 38/34 | Ragweed | 3 mo | Aqueous, modified |
| Welsh, 1981 [15] | 13-58 | 18/15 | Ragweed | 20 wk | Aqueous |
| Schumacher, 1982 [16] | 20-53 | 8/7 | Grass | 10 wk | Powder, modified |
| Georgitis, 1983 [17] | 16-67 | 31/13 | Grass | 10 wk | Aqueous, modified |
| Georgitis, 1984 [18] | Ad | 29/16 | Grass | 10 wk | Aqueous, modified |
| Andri, 1992 [19] | 14-54 | 8/8 | Parietaria | 18 wk | Powder, modified |
| Andri, 1993 [20] | 15-54 | 11/10 | Mite | 12 mo | Powder |
| Passalacqua, 1995 [21] | 20-56 | 9/9 | Parietaria | 5 mo | Powder |
| D'Amato, 1995 [22] | 13-37 | 10/10 | Parietaria | 8 mo | Powder |
| Andri, 1995 [23] | 17-56 | 14/14 | Birch | 22 wk | Powder |
| Fanales-Belasio, 1995 [24] | 16-49 | 10/10 | Mite | 3 mo | Aqueous |
| Andri, 1996 [25] | 14-52 | 13/15 | Grass | 4 mo | Powder |
| Cirla, 1996 [26] | 17-44 | 11/11 | Birch/alder | 4 mo | Powder |
| Bardare, 1996 [27] | 5-15 | 19/20 | Grass | 3 mo | Powder |
| Gaglani, 1997 [28] | 18-35 | 13/14 | Weed mix | 4 mo | Aqueous |
| Bertoni, 1999 [29] | 18-43 | 10/10 | Grass | 3 mo | Aqueous |
| Motta, 2000 [30] | 13-55 | 55/47 | Grass/mite | 8 mo | Aqueous |
| Pocobelli, 2001 [31] | 16-45 | 22/21 | Grass | 4 mo | Powder, modified |
| Marcucci, 2002 [32] | 4-15 | 16/16 | Mite | 18 mo | Powder, modified |
| Passali, 2002 [33] | 16-47 | 18/18 | Mite | 8 mo | Powder, modified |